OASIS® Matrix is similar to human skin

Porcine small intestinal submucosa (SIS) is a naturally derived extracellular matrix (ECM) scaffold similar to that found in human dermis2,4

Characteristics of OASIS Matrix and Human Dermis

Components2,5-8,a Normal physiological function in human dermis5-8 OASIS Matrix Human dermis
Collagens
Type I, III, IV, VI2,5 Cell guidance and migration, structure and support5,7
Elastin Contributes to tissue elasticity6
GAGs
Heparin2 Binds growth factors; anticoagulant7
Hyaluronic acid2,8 Maintains moisture, decreases inflammation8
Chondroitin2 Binds growth factors; cell adhesion and proliferation2
Glycoproteins
Fibronectin2,6,7 Cell proliferation, migration, and attachment7
Lamininb,2,7 Cell proliferation, migration, and attachment7
Entactin2 Cell proliferation, migration, and attachment2
Proteoglycans
Decorin6 Regulates collagen fibril structure, cell migrators; binds growth factors6
HSPG6 Binds growth factors7

aComponents identified in vivo (nonhuman) and/or in vitro.

bPresent in SIS cultured with cells.

GAGs = glycosaminoglycans; HSPG = heparan sulfate proteoglycan.

OASIS Matrix supports good wound care regimens

  • Good wound care is the foundation of wound management
  • Wound closure is improved when good wound care is combined with OASIS Matrix13,14
  • Works with a variety of secondary dressings9
  • Maintains moisture balance4

OASIS ULTRA Tri-Layer Matrix supports multiple wound closure techniques

  • Commonly used to support wounds closed via secondary intention
  • May support complex interventions, including delayed primary closure or preparation for a graft or flap

Migration of host cells to the wound helps support formation of granulation tissue10,11

In vivo animal model10,c
Cellular infiltration into the SIS material Vascular ingrowth into the SIS material
Dots indicate cells* Blood vessels

 In vivo animal model10

cThe clinical significance of these data is not established.

*Fibroblasts and PC12 cells16