OASIS® Matrix is similar to human skin

Porcine small intestinal submucosa (SIS) is a naturally derived extracellular matrix (ECM) scaffold similar to that found in human dermis3-14

Characteristics of OASIS Matrix and Human Dermis

Components3-14 Normal physiological function in human dermis3,4,15-21,23 OASIS Matrix Human dermis
Type I, III, IV, VI6-10 Cell guidance and migration, structure and support15,18
Elastin11 Contributes to tissue elasticity4
Heparin12 Binds growth factors; anticoagulant15,19
Hyaluronic acid5,12 Maintains moisture, decreases inflammation16
Chondroitin12 Binds growth factors; cell adhesion and proliferation19
Fibronectin5 Cell proliferation, migration, and attachment15,20
Laminin10 Cell proliferation, migration, and attachment15,21
Entactin3,13 Cell proliferation, migration, and attachment3
Decorin4,13 Regulates collagen fibril structure, cell migrators; binds growth factors23
HSPG14 Binds growth factors15,17

GAGs = glycosaminoglycans; HSPG = heparan sulfate proteoglycan.

OASIS Matrix supports good wound care regimens

  • Good wound care is the foundation of wound management
  • Wound closure is improved when good wound care is combined with OASIS Matrix24,25
  • Works with a variety of secondary dressings26,27

OASIS ULTRA Tri-Layer Matrix supports multiple wound closure techniques

  • Commonly used to support wounds closed via secondary intention25
  • May support complex interventions, including delayed primary closure or preparation for a graft or flap27

Migration of host cells to the wound helps support formation of granulation tissue28,29

In vivo animal model28,*
Cellular infiltration into the SIS material Vascular ingrowth into the SIS material
Dots indicate cells Blood vessels

 In vivo animal model28

cThe clinical significance of these data is not established.