OASIS® Matrix is similar to human skin

Porcine small intestinal submucosa (SIS) is a naturally derived extracellular matrix (ECM) scaffold similar to that found in human dermis3-14

Characteristics of OASIS Matrix and Human Dermis

Components3-14 Normal physiological function in human dermis3,4,15-21,23 OASIS Matrix Human dermis
Collagens
Type I, III, IV, VI6-10 Cell guidance and migration, structure and support15,18
Elastin11 Contributes to tissue elasticity4
GAGs
Heparin12 Binds growth factors; anticoagulant15,19
Hyaluronic acid5,12 Maintains moisture, decreases inflammation16
Chondroitin12 Binds growth factors; cell adhesion and proliferation19
Glycoproteins
Fibronectin5 Cell proliferation, migration, and attachment15,20
Laminin10 Cell proliferation, migration, and attachment15,21
Entactin3,13 Cell proliferation, migration, and attachment3
Proteoglycans
Decorin4,13 Regulates collagen fibril structure, cell migrators; binds growth factors23
HSPG14 Binds growth factors15,17

GAGs = glycosaminoglycans; HSPG = heparan sulfate proteoglycan.

OASIS Matrix supports good wound care regimens

  • Good wound care is the foundation of wound management
  • Wound closure is improved when good wound care is combined with OASIS Matrix24,25
  • Works with a variety of secondary dressings26,27

OASIS ULTRA Tri-Layer Matrix supports multiple wound closure techniques

  • Commonly used to support wounds closed via secondary intention25
  • May support complex interventions, including delayed primary closure or preparation for a graft or flap27

Migration of host cells to the wound helps support formation of granulation tissue28,29

In vivo animal model28,*
Cellular infiltration into the SIS material Vascular ingrowth into the SIS material
Dots indicate cells Blood vessels

 In vivo animal model28

cThe clinical significance of these data is not established.