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Pre-clinical Research Comparing OASIS® Wound Matrix to ORC/Collagen (Regenerated Matrix)
 

The clinical significance of these data have not
been established

 

Study Design1

The mouse subcutaneous implant method was used for the investigation of in vivo angiogenesis and cellular infiltration.

  • SIS wound matrix and oxidized regenerated ORC sheets were made into discs that were then implanted subcutaneously into mice (10 SIS, 10 ORC, 2 implants per mouse). Samples were rehydrated before implantation
  • Vessel ingrowth was assessed at Day 21 after implantation using fluorescence microangiography and histology

 

Substantial Angiogenesis in an animal model

Results: When compared to ORC/collagen, the SIS environment of OASIS® Wound Matrix was associated with more angiogenesis in a murine model1

  • OASIS® Wound Matrix revealed substantial blood vessel ingrowth1
  • In contrast, minimal blood vessel ingrowth was observed with ORC/collagen1

Substantial Angiogenesis: OASIS Wound Matrix - natural matrix and ORC/collagen regenerated matrix

 

Evident Cellular Infiltration in an animal model

Results: When compared to ORC/collagen, the OASIS® Wound Matrix histology demonstrated an association with more cellular infiltration in a murine model1

Evident Cellular Infiltration: OASIS Wound Matrix - natural matrix and ORC/collagen regenerated matrix

Hematoxylin- and eosin- (H&E) stained sections of SIS and ORC/collagen discs showed cellular infiltration 21 days after subcutaneous implantation into mice1

 

 

Reference: 1. Data on file, Cook Biotech, Inc.


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